Rudy's primary work is on Alzheimer's. In this disease, beta amyloid proteins form plaques in the brain and kill nerve cells eventually leading to dementia. Research from Washington University School of Medicine in St. Louis shows that when people's brains are in a Delta brain wave state, beta amyloid production in the brain ceases and the toxic material is cleared away. One thought is to explore the possibility of using brain entrainment technology to help treat Alzheimer's, but at this point all it is being used for is to help people meditate, relax and dream instantly and effortlessly.
I call the kind of intuitions and inspirations that come when we meditate and do these kinds of practices my “marching orders.”Okay, this is what I need to do. We’re not using our brilliant linear minds here; that’s not the place wisdom comes from. The place of wisdom is, again, relaxing into these states with loving-kindness, and then all the stuff can come out, whether we are dealing with our shadow issues or dealing with our light issues—the wisdom and gifts we haven’t yet brought forth that need to be birthed.
Anyone who has sought out different methods for enhancing cognitive ability will probably have come across a technique known as Brainwave Entrainment. However, it is a fairly niche area of brain training, meaning that this form of stimulation is often overlooked in favour of more mainstream methods. The following outlines what Brainwave Entrainment actually is, how it is used, and some of the benefits attributed to it.
Many of our common symptom-soothing formulas are designed to take effect within 5-10 minutes if used properly. To get these fast-acting results, we recommend 3-4 droppers full, or 6-8 pumps, per use to start. If you are not yet feeling the full effect within the first 5 minutes, repeat the original serving. You can do this up to 4 servings back to back. Note that some of our formulas are tonics and are meant to work over longer periods of time.
There’s also some new stuff I’ve certainly never included in tracks before including some gentle pink noise and brown noise blended together in the background with what’s called phase modulation. This is almost outside of awareness as you’re listening to it. This is how your ear tells what direction a sound is coming from. Does it arrive at your left ear slightly before your right ear? You can modulate that. So, again, it has a very gentle, imperceptible rhythmic quality to it.
Today we're going to put on our headphones, kick back in the beanbag, and get mellow to the soothing sounds of the latest digital drug: binaural beats. These computer generated sound files are said to massage your brain and produce all sorts of effects, everything from psychedelic experiences to behavior modification. Let's point our skeptical eye at the science of binaural beats, and especially at some of the claims made for them.
It should be stated that if we are listening to LifeFlow and we are intentionally seeking to enter into meditation, the chances are good that we will do exactly that rather than just being in a daydream or some other pleasant state. It’s no guarantee, but the combination of meditation and brainwave entrainment raises the odds that we will accomplish our meditative goal.

Consider the following analogy. Imagine a ballroom full of people dancing together. When the music changes to a faster tempo, the dancers move faster in response to this. When a slower piece of music is played, the dancers’ rhythm slows down as well. In a similar way, the frequency of your brain will change in response to the frequency of the binaural beat that it is exposed to. For example, a person who is in a state of very deep meditation may have a dominant brainwave frequency of 5 hertz, so by listening to a binaural beat with a frequency of 5 hertz you can entrain your own brainwaves to a similar state.

Although there is a general stress response pattern, there can be variations in the response according to the characteristics of the stressor (10). Individuals tend to respond differently based on the familiarity of the stressor. For example, the perceived level of stress and physiological response when giving a presentation to a group of work colleagues will likely be less than when presenting to an unfamiliar group. The stress response also varies depending on the level of perceived control one has over the stressor (10). If there is a way for one to actively cope with the stressor that is reasonable, then the individual usually perceives more control over the situation. Consider an individual who has to take a certification examination for work and has 6 months to prepare. He can adjust his schedule to accommodate study time. However, waiting for medical test results that show whether one has a serious illness does not allow a sense of control over the stressor, and the individual passively endures the stressor or may try to avoid the stressor. With this uncontrollable type of stressor, there is a more negative reaction with greater productions of cortisol, which can have damaging health effects because of the suppression of immune function (10).
Theta waves are associated with ➤ Increased sense of inner peace and emotional stability ➤ Deep relaxation ➤ Improved memory ➤ Heightened intuition and inspiration ➤ Calms the chatter of your mind ➤ Increased psychic abilities and sense of spiritual connection ➤ Speed healing, improved physical healing ➤ More restful sleep ➤ Release beneficial hormones related to health and longevity ➤ Reduce mental fatigue ➤ Reduction of anxiety and stress
... Audio visual stimulation effects people on two levels: Budzynski (2001) reports significant improvement of mental capabilities after AVS in 75-year old male. Cruceanu and Rotarescu (2013) proved that the exposure to 30-minutes of audio-visual stimulation with the frequency of 10,2 Hz significantly improves cognitive skills. Based on their research, authors claim that people need to be exposed to AVS at least for 20 minutes in order to achieve positive effects. ...
Passively listening to binaural beats may not spontaneously propel you into an altered state of consciousness. One's subjective experience in response to binaural-beat stimulation may also be influenced by a number of mediating factors. For example, the willingness and ability of the listener to relax and focus attention may contribute to binaural-beat effectiveness in inducing state changes. "Ultradian rhythms in the nervous system are characterized by periodic changes in arousal and states of consciousness (Rossi, 1986).

However, yoga and meditation take time to learn and master, and until the student becomes proficient, progress can be slow and frustrating, leading many people to abandon the effort before they see the benefits. Brainwave entrainment has the potential for helping a person enter the relaxing and rejuvenating mind-states brought about by yoga and meditation without the learning curve and time needed for mastering these other techniques. Brainwave entrainment may even facilitate learning other mindfulness methods by helping a person achieve success faster and more reliably. 

Infra-Low brainwaves (also known as Slow Cortical Potentials), are thought to be the basic cortical rythms that underlie our higher brain functions. Very little is known about infra-low brainwaves. Their slow nature make them difficult to detect and accurately measure, so few studies have been done. They appear to take a major role in brain timing and network function. 
Another very useful application for the Theta & Delta frequencies is to keep your eyes open while listening to the entrainment recordings. Simply pick a spot on the wall and look beyond it as if you were looking at the view beyond the wall. Keeping your eyes open while in Theta and Delta brainwave states stimulates connections between the visual information processing centers of your brain and the "dream vision" centers that normally only function with the eyes closed.
Let’s face it, the stress we face today isn’t going anywhere, which is exactly why it’s more important than ever to find natural ways to bust stress that work well for us. If you’re up against large amounts of stress in your life (and who isn’t?), studies show you can greatly benefit from carving out more time in your busy schedule for things like regular exercise, meditation, spending time outdoors and keeping up with fun hobbies.
Today, EEG machines are used for diagnosing epilepsy and sleep disorders, for determining dosages for anesthesia, and measuring the brain activity of people in comas or suffering from brain trauma. EEG machines also continue to play a role in researching and understanding brainwave entrainment and developing new and better methods for delivering the benefits of this form of brainwave modification. 
I am fortunate to be working with Deepak Chopra, M.D., and Dr. Rudy Tanzi, co-authors of the bestselling book Super Brain, on a technology called Brain Wave Entrainment. Deepak is very well known, but Rudy is an amazingly interesting person as well. He is the Kennedy Professor of Neurology at Harvard Medical School and Vice-Chair of Neurology at Mass General Hospital. Rudy co-discovered three of the four original Alzheimer's genes and today runs the Alzheimer's Genome Project. He also plays the keyboards, including, at times, for Aerosmith. He is kind of a real life "Buckaroo Banzai."
According to Dr. Mark Hyman, eating whole, real foods restores balance and reduces the effects of stress on your body. Replacing harmful substances such as caffeine, alcohol, and refined sugars, with clean proteins, fruits, vegetables, and healthy fats helps regulate your hormone levels, including stress hormones. Food As Medicine Education Director Kathie Swift, MS, RDN, LDN, FAND, EBQ cites the connection between the gut and brain in relieving stress. The gut and brain are constantly sending signals to each other, so by keeping your microbiota (the bacteria in your gut) healthy, your brain feels less stressed.

A 2008 study at Hofstra University played two different binaural beats and a control sound (a babbling brook) to patients with high blood pressure. There was no difference between the groups. In one small study from Japan that was published in the Journal of Neurophysiology in 2006, they played various binaural beats to nine subjects, and observed the resulting EEGs. They found great variability in the results. Their conclusion was that listening to binaural beats can produce activity on the human cerebral cortex, however the cause was more likely a conscious auditory reaction and was not correlated to the frequency of the binaural beat. However, a 2005 study published in Clinical Neurophysiology found that they were able to induce a desired frequency in the EEG matching the phantom beat frequency encoded in a binaural beat, however this was with a single subject and was neither blinded nor controlled.
Our brainwave states are natural. Guiding the brain into those states intentionally by using entrainment is just another way of experiencing those same natural states. Nothing “unnatural” is produced by the brain as a result of using entrainment. The only thing that is different is that when using entrainment we often go into the experience with either general expectations, or a well defined laundry list of specific expectations that we associate with entrainment. We have no such list going throughout our normal day when we’re not using entrainment.
Alpha: Alpha brainwave patterns are associated with a state of wakeful relaxation. Slower and lower in frequency (between 9-14 hertz), alpha waves are dominant when we’re calm and relaxed, but still alert. Alpha waves are associated with states of meditation (your yoga class probably puts you in an alpha state), and also with our ability to be creative.

Gamma waves are the fastest of the brainwave frequencies (high frequency band of brainwave activity) which signifies the highest state of focus possible. They are associated with peak concentration and the brain’s optimal frequency for cognitive functioning – the 40 Hz frequency corresponds to a Schumann resonance band and many scientists, including Nobel Laureate Sir Francis Crick believe that it may be the key to the act of cognition. The Gamma state relates to simultaneous processing of information from different brain areas; information passes very rapidly.

Effects on cortisol: The hormone cortisol is commonly associated with stress, and when levels are higher than usual, it can have a negative impact on the body. High levels of cortisol can lead to a range of conditions, including Cushing syndrome, menstrual cycle and female libido changes, anxiety, and depression. Dr. Giampapa noted a reduction of cortisol of up to 70-80 percent in several study participants.

For example, if a 530 Hz pure tone is presented to a subject's right ear, while a 520 Hz pure tone is presented to the subject's left ear, the listener will perceive the auditory illusion of a third tone, in addition to the two pure-tones presented to each ear. The third sound is called a binaural beat, and in this example would have a perceived pitch correlating to a frequency of 10 Hz, that being the difference between the 530 Hz and 520 Hz pure tones presented to each ear.
“Stress and sleepless nights are closely linked,” Buenaver says. “If you’re in pain, tend to worry, or are coping with a difficult situation in your life, you may have more stress hormones than usual circulating in your body. A poor night’s sleep adds even more. And those hormones may never be fully broken down. It’s like running an engine in fifth gear all the time.”
Controlled or pre/post studies of the effects of BWE using auditory or visual stimulation were eligible for inclusion, provided pulses of light or tone were delivered at frequencies hypothesised to have a beneficial effect or in line with a protocol addressing clinical outcomes. Studies were required to report clinical or psychological outcomes (measured using standard methods or as deemed appropriate by peer review) and to report statistical analysis. Studies of outcomes such as electroencephalogram (EEG) response or neurotransmitter levels were not eligible. Case studies were excluded.