Effects on cortisol: The hormone cortisol is commonly associated with stress, and when levels are higher than usual, it can have a negative impact on the body. High levels of cortisol can lead to a range of conditions, including Cushing syndrome, menstrual cycle and female libido changes, anxiety, and depression. Dr. Giampapa noted a reduction of cortisol of up to 70-80 percent in several study participants.
Beta brainwaves are next highest in frequency after alpha waves, occurring at 13 to 30 hertz. Beta brainwaves are what we experience every day as we are awake and using our analytic mind. Beta brainwaves are needed for concentrating on mental tasks, and when they are present for too long of a time, they lead to stress, anxiety, and even paranoia. Most people do not have trouble achieving beta brainwaves and in fact suffer from spending too much time in beta brainwave patterns. However, those with attention deficit disorder (ADD) who have problems focusing their attention can benefit from learning how to achieve and remain in beta brainwave states for longer amounts of time.
“Stress” is a commonly used term, and it is often used with different meanings. The standard definition for stress that will be used in this article is the disruption of the body’s homeostasis or a state of disharmony in response to a real or perceived threat or challenge (8). The threatening or challenging situation is referred to as a “stressor.” When a person encounters a stressor, the body prepares to respond to the challenge or threat. The autonomic nervous and endocrine systems respond by producing the hormones epinephrine, norepinephrine, and cortisol. The result of this hormone production is a cascade of physiological reactions that make up the stress response. Epinephrine and norepinephrine are involved in the initial changes that take place to prepare the body to react and to prepare for a challenge. These responses include increases in heart and respiration rates, blood pressure, perspiration, and energy production (8). There also is a suppression of immune function, production of β-endorphin (the body’s natural pain killer), and increased acuity of the senses. These changes make up the fight-or-flight response, which prepares the body to cope with the stressor. If the stressor is perceived as negative or more as a threat than as a challenge, cortisol production is increased. Cortisol is involved in energy production but also suppresses immune function.
The composer Alvin Lucier has written many pieces that feature interference beats as their main focus. Italian composer Giacinto Scelsi, whose style is grounded on microtonal oscillations of unisons, extensively explored the textural effects of interference beats, particularly in his late works such as the violin solos Xnoybis (1964) and L'âme ailée / L'âme ouverte (1973), which feature them prominently (note that Scelsi treated and notated each string of the instrument as a separate part, so that his violin solos are effectively quartets of one-strings, where different strings of the violin may be simultaneously playing the same note with microtonal shifts, so that the interference patterns are generated). Composer Phill Niblock's music is entirely based on beating caused by microtonal differences.
Another very useful application for the Theta & Delta frequencies is to keep your eyes open while listening to the entrainment recordings. Simply pick a spot on the wall and look beyond it as if you were looking at the view beyond the wall. Keeping your eyes open while in Theta and Delta brainwave states stimulates connections between the visual information processing centers of your brain and the "dream vision" centers that normally only function with the eyes closed.
♥ I admit that I do not know much about brainwaves and can be swayed by suggestion (ah, the fickle subconscious), but since using this machine and sort of hiding the noise with other sounds or my own music so it is not so obvious to me, it has helped me get through my email correspondences and other online tasks with the focus that I need. Thank you so much for making this!

Resonant entrainment of oscillating systems is a well-understood principle within the physical sciences. If a tuning fork designed to produce a frequency of 440 Hz is struck (causing it to oscillate) and then brought into the vicinity of another 440 Hz tuning fork, the second tuning fork will begin to oscillate. The first tuning fork is said to have entrained the second or caused it to resonate. The physics of entrainment apply to bio-systems as well. Of interest here are the electromagnetic brain waves. The electrochemical activity of the brain results in the production of electromagnetic wave forms which can be objectively measured with sensitive equipment. Brain waves change frequencies based on neural activity within the brain. Because neural activity is electrochemical, brain function can be modified through the introduction of specific chemicals (drugs), by altering the brain's electromagnetic environment through induction, or through resonant entrainment techniques.

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Entrainment is a phenomenon seen is a wide variety of different natural circumstance. In the field of chronobiology, the study of biological rhythms in living organisms, entrainment is the synchronization of a circadian rhythm with the rhythm of an external pattern, such as the synchronizing of women’s menstrual cycles with the phases of the moon or with one another in a group.
When explaining this to others they frequently respond with something like, “But I had no expectation or even any idea that my face might experience flushing. I didn’t even know that was possible. Now every time I listen to a particular entrainment track that specific face flushing occurs. If it is a specific phenomena, and it only happens when I use one certain entrainment track, doesn’t that prove it is the entrainment causing it?”
Recent research at the University of Lisbon finally uncovered the reason for the 350 year-old mystery, finding that the resonance of sound is the mechanism for entrainment of swinging pendulums and ticking clocks, and it seems likely that the energy transferred by sound is also responsible for other observations of entrainment, including brainwave entrainment.

Transparent Corp's Research Area is arguably the most comprehensive resource for collated brainwave entrainment research.   Update: the main research area on Transparent Corp's website is currently being updated, so it is offline.  However, you can still access their peer-reviewed research paper as a PDF here: “A Comprehensive Review of the Psychological Effects of Brainwave Entrainment“.
Studies have shown binaural beats may affect levels of dopamine, a hormone that plays a broad role in cognition and a particular role in creative thinking. This has scientists examining the possibility that binaural beats can be used to stimulate creativity. (If you’re looking to be more creative and innovative in your thinking, keep in mind that sleep itself is a powerful tool!)

Binaural beats were discovered in 1839 by a German experimenter, H. W. Dove. The human ability to "hear" binaural beats appears to be the result of evolutionary adaptation. Many evolved species can detect binaural beats because of their brain structure. The frequencies at which binaural beats can be detected change depending upon the size of the species' cranium. In the human, binaural beats can be detected when carrier waves are below approximately 1000 Hz (Oster, 1973). Below 1000 Hz the wave length of the signal is longer than the diameter of the human skull. Thus, signals below 1000 Hz curve around the skull by diffraction. The same effect can be observed with radio wave propagation. Lower-frequency (longer wave length) radio waves (such as AM radio) travel around the earth over and in between mountains and structures. Higher-frequency (shorter wave length) radio waves (such as FM radio, TV, and microwaves) travel in a straight line and can't curve around the earth. Mountains and structures block these high-frequency signals. Because frequencies below 1000 Hz curve around the skull, incoming signals below 1000 Hz are heard by both ears. But due to the distance between the ears, the brain "hears" the inputs from the ears as out of phase with each other. As the sound wave passes around the skull, each ear gets a different portion of the wave. It is this waveform phase difference that allows for accurate location of sounds below 1000 Hz(9). Audio direction finding at higher frequencies is less accurate than it is for frequencies below 1000 Hz. At 8000 Hz the pinna (external ear) becomes effective as an aid to localization. In summary it's the ability of the brain to detect a waveform phase difference is what enables it to perceive binaural beats.
A person might wonder what the problem with looking for validation is; why we shouldn’t seek to compare our experiences with those others have had. Shouldn’t there be some sort of indicators that our practice is producing an effect? There are indicators, but they are not the high profile, odd phenomena most frequently looked for, and they may not become apparent immediately. Some things do take a little time.
The authors concluded that preliminary evidence suggested that brainwave entrapment was an effective therapeutic tool, but further research was required. The evidence presented appeared to justify the recommendation for further research. In view of the lack of controlled evidence and problems with methodology and reporting in the review, the authors’ conclusions regarding efficacy did not appear reliable.