If anybody would like to look over the scientific evidence concerning brainwave entrainment and isochronic tones, I’ve done a lot of research over the years which I’ve collected at the PubMed website of NCBI – a branch of the National Institute of Health – that provides access to a large library of medical journal articles. I’ve made my list public so you can look through the journal articles that were published concerning this topic. Here’s the link: http://www.ncbi.nlm.nih.gov/sites/myncbi/1tmDFOl0XtyA4/collections/51531796/public/. Most of the collection only gives access to abstracts or summaries unless you’re at some kind of educational institution that has a subscription to the particular journal that article is in, but I actually find abstracts really helpful. So have at it, read away. And if your psychiatrist/therapist thinks you’re nuts for feeling better after listening to isochronic tones, just whip out your 82-page collection of scientific journal abstracts written by her peers and give it to her to read. 🙂

... Several studies have looked at the possible effects of binaural beats within the alpha range on cognitive abilities. A significant improvement in cognitive processing, as measured by the Stroop Effect exercise, was found by a BB stimulation of 10.2 Hz frequency (Cruceanu & Rotarescu, 2013).Carter and Russell (1993)exposed 8 to 12 year old boys with learning disabilities to 8-week long 10 and 18 Hz BB stimulation sessions, and they found an improvement in Raven's progressive matrices and in a subtest of auditory sequential memory (Carter & Russell, 1993).McMurray (2006)assessed the effect of 7 and 11 Hz BB on alpha brainwave activity, working memory, and attention in healthy elderly people, who are known for experiencing gradual decrease in physiological alpha activity. The 2 minutes exposure to BB resulted in an altered electrical activity in the brain. ...

Are you someone who has turned to meditation or yoga as a way of relieving stress and improving your overall well-being? Yoga and meditation are time-proven methods, used for centuries, which restore mental, physical, and spiritual balance in people’s lives, and brainwave entrainment can be used in conjunction with these practices for even deeper levels of benefit. 
Binaural beats are auditory brainstem responses which originate in the superior olivary nucleus of each hemisphere. They result from the interaction of two different auditory impulses, originating in opposite ears, below 1000 Hz and which differ in frequency between one and 30 Hz (Oster, 1973).For example, if a pure tone of 400 Hz is presented to the right ear and a pure tone of 410 Hz is presented simultaneously to the left ear, an amplitude modulated standing wave of 10 Hz, the difference between the two tones, is experienced as the two wave forms mesh in and out of phase within the superior olivary nuclei. This binaural beat is not heard in the ordinary sense of the word (the human range of hearing is from 20-20,000 Hz). It is perceived as an auditory beat and theoretically can be used to entrain specific neural rhythms through the frequency-following response (FFR)--the tendency for cortical potentials to entrain to or resonate at the frequency of an external stimulus. Thus, it is theoretically possible to utilize a specific binaural-beat frequency as a consciousness management technique to entrain a specific cortical rhythm.  
The binaural-beat appears to be associated with an electroencephalographic (EEG) frequency-following response in the brain (3). Many studies have demonstrated the presence of a frequency-following response to auditory stimuli, recorded at the vertex of the human brain (top of the head). This EEG activity was termed "frequency-following response" because its period corresponds to the fundamental frequency of the stimulus (Smith, Marsh, & Brown, 1975). Binaural-beat stimulation appears to encourage access to altered states of consciousness.
By exposing an individual to repeatedly external stimulus which can be flashing lights and/or recurring sounds, the entrainment process consists in pushing the brain to adjust to match the frequency provided. Unlike other forms of neurotherapy which require the individual to actively respond to stimulus, entrainment creates an immediate neurophysical response which is instinctive and effortless for the person being provided with the light and/or sound combinations. The key outcome of the sensory stimulation is known as the ‘Frequency Following Response’.
Sleep and stress tend to cause a vicious cycle – if you’re stressed, then you can’t sleep, which makes you ill-prepared to handle the stressors of the next day, leading to more stress. To relieve stress before bed, try some relaxation techniques (see below) and disconnect from technology as much as possible an hour before bedtime. To ensure the proper amount of rest (7-8 hours is recommended), set an alarm reminding you to go to bed.

The Transparent Corp forum – This forum is an invaluable resource for any brainwave entrainment user or enthusiast.  Most of the feedback is obviously focused on the Transparent Corp software, but with over 20,000+ posts now you can find answers to the whole array of brainwave entrainment questions on there.  (UPDATE: Sadly, the Transparent Corp forum has now been taken offline)
It might seem obvious that you’€™d know when you’€™re stressed, but many of us spend so much time in a frazzled state that we’ve forgotten what it feels like when our nervous systems are in balance: €”when we’€™re calm yet still alert and focused. If this is you, you can recognize when you’re stressed by listening to your body. When you’re tired, your eyes feel heavy and you might rest your head on your hand. When you’re happy, you laugh easily. And when you’re stressed, your body lets you know that, too. Get in the habit of paying attention to your body’€™s clues.
Regarding split hemisphere isochronic tones. Think of this as two separate isochronic tones tracks playing independently of each other, one playing in one ear and the other one in the opposite ear. Better still, imagine someone playing and recording a drum beat at a rate of 5 taps per second (5Hz – 5 cycles per second). Then a separate recording of a drum beat is made at a rate of 10 taps per second (10 Hz). You then make an audio track where the left ear/channel hears the 5 drum beats recording and the right ear/channel hears the 10 beat recording. With headphones on, each ear can only hear each respective drum beat and not the other. So you are hearing two different beat recordings at the same time, but it’s different in each ear. A split hemisphere isochronic tones track works just the same. You hear two beats at the same time, not two tones as with binaural beats that create a single beat, but two different speeds of beats in each ear. This is what enables you to stimulate and influence each side of the brain with a different frequency of beat. Binaural beats can only stimulate and influence a whole brain effect using a single beat.
Binaural beats are an auditory illusion where two oscillators, slightly detuned from each other, are played simultaneously with one perceived by each ear. The human brain mixes the audio from each ear, and the listener perceives a "beating" effect that isn't actually there. This is a well-studied phenomenon that has gained the interest of audiologists and neurologists, but it's most famous for being picked up by the alternative medicine community as a way to get high.
Thanks for the reply. I am now clearer on ‘what’ is heard. Can you expand or point me in direction ..a bit more about ‘pitch frequency’ and frequency spoken about and what exactly is the difference ..and how we use the higher pitch frequencies to ‘hear’ or become aware of them? Would you only pick up the low freq on a EEG?. sorry for being pedantic ..it still does not clear up split isochronics and possibly creating same situation as binaural beats..
Research shows that binaural beats can literally drive brain activity into specific brain states (Gamma, Beta, Alpha, Theta or Delta). Without any effort and naturally, you would have your brain activity to synchronize with the binaural beat; it will become organized and coherent, and eventually, the left and right hemispheres of your brain will start to be balanced creating a very unique state called “hemispheric synchronization” (equal frequency and amplitude of the wave forms in both hemispheres). This extraordinary brain state is very powerful and normally unattainable without this kind of stimulation. Through the entrainment of brain waves, binaural beats can influence the brain in a very subtle way, inducing states of relaxation, sleep, meditation, creativity…
The most common way to use a brainwave entrainment is for a short-term benefit, to help guide your brain into a particular mental state at the time you need it.  In a similar way to how you might take a sleeping pill before bed to help you get to sleep, or maybe drink some coffee or an energy drink to help wake you up and give you a boost of energy.
The Neuro Programmer website, as is typical, is full of testimonials and vague references to research. I tried to track down the research they referenced, but could not find anything published or peer-reviewed by the authors named or on the subjects indicated. For example, they cite one study by Thomas Budzynski, but the only thing published by him that is listed on Pub Med is a small study on biofeedback published in 1969. The 1999 study they reference is not listed. Also – Budzynski has connections to another company – Theta Technologies – which sells similar technology.  (The exact nature of his connection is not clear, he was at least a consultant. He is also listed as the director of research for another company, Synchromed, LLC.)  This looks like just another in-house worthless study to support the marketing of a product.

The functional role of neural oscillations is still not fully understood;[6] however they have been shown to correlate with emotional responses, motor control, and a number of cognitive functions including information transfer, perception, and memory.[7][8][9] Specifically, neural oscillations, in particular theta activity, are extensively linked to memory function, and coupling between theta and gamma activity is considered to be vital for memory functions, including episodic memory.[10][11][12]