Binaural-beat perception originates in the inferior colliculus of the midbrain and the superior olivary complex of the brainstem, where auditory signals from each ear are integrated and precipitate electrical impulses along neural pathways through the reticular formation up the midbrain to the thalamus, auditory cortex, and other cortical regions.[6]
When tuning instruments that can produce sustained tones, beats can be readily recognized. Tuning two tones to a unison will present a peculiar effect: when the two tones are close in pitch but not identical, the difference in frequency generates the beating. The volume varies like in a tremolo as the sounds alternately interfere constructively and destructively. As the two tones gradually approach unison, the beating slows down and may become so slow as to be imperceptible. As the two tones get further apart, their beat frequency starts to approach the range of human pitch perception[1], the beating starts to sound like a note, and a combination tone is produced. This combination tone can also be referred to as a missing fundamental, as the beat frequency of any two tones is equivalent to the frequency of their implied fundamental frequency.
John Dupuy is the CEO of iAwake Technologies and travels internationally to teach and inspire on the subjects of Integral Recovery, Integral Transformative Practice, and the use of brainwave entrainment technology to deepen one’s meditation practice and in the treatment of addiction, depression, and PTSD. John is the founder of Integral Recovery® and his book Integral Recovery: A Revolutionary Approach to the Treatment of Alcoholism and Addiction  won the 2013 USA Best Book Award. John also hosts interviews with leading innovators in the spiritual technologies field on Spiritual Technologies 2.0 Live and co-hosts the popular Journey of Integral Recovery podcast.
A popular opinion in the brainwave entrainment community is that listening to isochronic tones without music produces a much stronger effect.  However, in the study by Doherty, Cormac. “A comparison of alpha brainwave entrainment, with and without musical accompaniment” (2014),  it was concluded that brainwave entrainment was equally effective for isochronic tones, both with and without music.

Although the binaural beats / music / downloads on this site contribute to wellness, they are not intended as a replacement for medical or psychological treatment. No medical claims are intended express or implied. Despite the fact that all statement made on this website are supported by research, no statements have been evaluated or approved by the U.S. Food and Drug Administration or any other international governance responsible for health care.
Generally speaking, the brain will usually entrain to the strongest stimulus which would be isochronic tones over binaural beats. So when you see people add binaural beats at a different frequency to the isochronic tones, that would not produce additional brainwave entrainment at another frequency. If they are both at the same frequency I haven’t seen any research to indicate whether that would be beneficial or not, but my belief is that it would weaken the potential for entrainment. When you look at the waveform of an isochronic tone there is a distinct empty space between each beat, making it very pronounced and effective. When you add binaural beats at the same frequency it looks like this: http://www.mindamend.com/wp-content/uploads/2017/11/isochronic-tones-binaural-beats-combined-waveform.jpg. The depth of the waveform is now half as deep and less effective. This is before the binaural beats are formed inside your head, where the waveform is hard to determine and measure. From listening to that type of combination the beats sound much less pronounced, which has to make them much less effective in terms of a brainwave entrainment stimulus, compared to isochronic tones on their own.
Social interaction is your body’s most evolved and surefire strategy for regulating the nervous system. Talking face-to-face with a relaxed and caring listener can help you quickly calm down and release tension. Although you can’€™t always have a pal to lean on in the middle of a stressful situation, maintaining a network of close relationships is vital for your mental health. Between sensory-based stress relief and good listeners, you’ll have your bases covered.
The phenomena of brainwave entrainment was first described in the scientific literature in 1973 by Gerald Oster in results published in an article in Scientific American entitled, “Auditory Beats in the Brain”. He showed that a specific brainwave could be induced when a person heard two separate, but closely related, sound frequencies, one in each ear. He discovered that when the frequencies heard by each ear differed by about 10 hertz, the brainwave pattern of the person hearing the sound would synchronize to the difference between the two frequencies. For example, if the person heard a 410 hertz sound in one ear and a 400 hertz sound in the other ear, their brainwaves would stabilize at the difference between the two, or 10 hertz. This technique is called binaural beats, and it is a fundamental principle of brainwave entrainment methods.
Many of our common symptom-soothing formulas are designed to take effect within 5-10 minutes if used properly. To get these fast-acting results, we recommend 3-4 droppers full, or 6-8 pumps, per use to start. If you are not yet feeling the full effect within the first 5 minutes, repeat the original serving. You can do this up to 4 servings back to back. Note that some of our formulas are tonics and are meant to work over longer periods of time.
From a brainwave entrainment effectiveness perspective, it’s my understanding that the response from isochronic tones stimulation starts to diminish over 30Hz and that 40Hz is about the limit for using them. So from what I’ve read on the topic a 100Hz beat wouldn’t work, probably because it’s too fast for the brain to process and synchronise with it.
But the notion of changing brain waves is a very appealing one, from a marketing stand point. People can visualize brain waves and we like synchrony. Also, in the computer age, we understand the notion of “programming.” We also have been prepped for the future by movies such as The Matrix, where people could master Kung Fu in minutes by simply “downloading” the knowledge. This gives the whole notion a superficial plausibility. But the science just isn’t there.

Hey, even before we spoke about creating Journey, I was thinking about how people across the world do their spiritual practices and the commonalities between them all. I was thinking, there is the path of stillness—which links right back to what we were talking about getting to a state of deep, profound relaxation and bringing clarity into stillness. Then there’s the path of rhythm, of rocking, of dancing. But there’s always a rhythm to it—even in the movements of Tai Chi, there’s a smoothness, a smooth rhythm. What it never is, is arrhythmic—those are the movements of a more anxious, frightened animal kind of thing. 


Isochronic tones have only been proven to have an effect while you are listening to them, that’s why you won’t find me claiming anywhere that there are potentially positive long-term effects. Once the tones stop, your brainwaves are no longer being stimulated by the sound and so they stop being in sync with the tone frequency. For you to think you are still feeling the effects after all this time and from such a short time listening to them, I think it may be linked to anxiety. I know that some people who are new to this type of thing can build up a strong feeling of anxiety, after worrying about the potential effects brought on by fear of the unknown. I suspect the problem may be psychological with you worrying about the potential effects and keep repeating the experience from memory in your head. When you keep going over the same thing in your head like that and worrying about it, it’s easy to then spot other potential side-effects like how your nostrils and body temp is feeling, then making links back to that experience and labelling that as the reason. I think the best way to overcome this is to realise that the side-effects you are mentioning are completely unrelated, so there is nothing to worry about. These tracks are literally listened to for millions of hours a month on YouTube across loads of channels. If the effects lasted for a long time people would just listen for 5 minutes and come back in a couple of weeks. But people keep coming back to listen because that’s the only way to feel the benefit and effects…while you are listening to them. If you are unable to stop thinking and worrying about this on our own, I recommend that you speak to your doctor about it or a specialist in dealing with anxiety issues. I hope that helps.
When signals of two different frequencies are presented, one to each ear, the brain detects phase differences between these signals. "Under natural circumstances a detected phase difference would provide directional information. The brain processes this anomalous information differently when these phase differences are heard with stereo headphones or speakers. A perceptual integration of the two signals takes place, producing the sensation of a third "beat" frequency. The difference between the signals waxes and wanes as the two different input frequencies mesh in and out of phase. As a result of these constantly increasing and decreasing differences, an amplitude-modulated standing wave -the binaural beat- is heard. The binaural beat is perceived as a fluctuating rhythm at the frequency of the difference between the two auditory inputs. Evidence suggests that the binaural beats are generated in the brainstem's superior olivary nucleus, the first site of contra-lateral integration in the auditory system (Oster, 1973). Studies also suggest that the frequency-following response originates from the inferior colliculus (Smith, Marsh, & Brown, 1975)" (Owens & Atwater, 1995). This activity is conducted to the cortex where it can be recorded by scalp electrodes.  
Other entrainment methods sometimes used include autopan modulation that moves sound in an 180º arc to create a desired tone. Harmonic box entrainment, invented by James Mann, uses a layering of binaural and monaural tones that alternate between ears, requiring headphones. Sound modulation and filtering, amplitude modulation, and pitch panning use diverse sounds to create rhythmic pulses matched to the desired brainwave frequency. 

To get a full answer you should really get in touch with the owner of the app, because it does really depend on how their track is constructed and how they intend it to work. I have one 50-minute sleep track which takes you down into delta (http://www.mindamend.com/shop/sleeping-and-dreaming/sleep-induction-isochronic-tones/) and that is designed to just get you to sleep, so you just let play until the end. If you played that track on repeat it might make you jump and wake you up, as the track begins at a higher frequency. I have another 8-hour sleep track which is meant to be played all throughout the night (http://www.mindamend.com/shop/sleeping-and-dreaming/deep-sleep-8-hour-sleep-cycle/). So it does depend on the individual track you are using.

Entrainment is a physics principle in which one rhythmic system falls in synchrony with another rhythmic system. If you’ve ever found yourself moving your body to the beat of your favorite song, then you’ve experienced entrainment in its most basic form. Besides music, this principle can be found all around you, probably more than you realize. Here are a few examples:
Studies have shown binaural beats may affect levels of dopamine, a hormone that plays a broad role in cognition and a particular role in creative thinking. This has scientists examining the possibility that binaural beats can be used to stimulate creativity. (If you’re looking to be more creative and innovative in your thinking, keep in mind that sleep itself is a powerful tool!)
Using a small amount of alcohol in the Pregnancy and Children's lines was a conscious decision. It enables us to keep the strength and efficaciousness of the formula intact but is also gentle and appropriate for women and children. Extracts made with only glycerine or water limit the constituent profile. WishGarden's finished extract contains a minimal amount of alcohol, which, per serving, is at a very low dietary level (similar to what is found in kombucha and ripe bananas). You can also further reduce the alcohol content by stirring your droppers full, or pumps, into hot water or tea for a few minutes.
The Frequency following response (FFR), also referred to as Frequency Following Potential (FFP), is a specific response to hearing sound and music, by which neural oscillations adjust their frequency to match the rhythm of auditory stimuli. The use of sound with intent to influence cortical brainwave frequency is called auditory driving,[39][40] by which frequency of neural oscillation is 'driven' to entrain with that of the rhythm of a sound source.[41][42]
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