Rudy's primary work is on Alzheimer's. In this disease, beta amyloid proteins form plaques in the brain and kill nerve cells eventually leading to dementia. Research from Washington University School of Medicine in St. Louis shows that when people's brains are in a Delta brain wave state, beta amyloid production in the brain ceases and the toxic material is cleared away. One thought is to explore the possibility of using brain entrainment technology to help treat Alzheimer's, but at this point all it is being used for is to help people meditate, relax and dream instantly and effortlessly.

Entrainment is a principle of physics which appears in biology, chemistry, neurology, medicine, astronomy etc. It is defined as the synchronization of two or more rhythmic cycles. In the seventeenth century, Dutch scientist Christian Huygens found out that by placing two unsynchronized clocks side by side on a wall, they would slowly synchronize to each other in a very accurate way. The clocks were the first example of spontaneous synchronization, a phenomenon found throughout nature from cells to the Solar System.
Most of all, don't feel bad if you fall asleep. Your brain is still receiving many of the benefits of entrainment while you sleep through the audio tracks. In fact, many people report better, more restful sleep when they use brainwave entrainment to help them fall asleep. However, I recommend that you do not go to sleep with your brainwave track set to repeat, as that can be too much stimulation for the brain.

Your brainwave activity during sleep is largely distinct from your brain activity when you’re awake. (REM sleep is one exception to this—during REM, your brain is active in ways very much like when you’re awake.) During non-REM sleep, the slower, lower frequency theta and delta waves dominate, compared to the alpha and beta waves that are prominent when you’re alert and active.
Brain waves are electrical activity patterns caused by the neurons of the brain communicating with each other. Brain waves can be detected using sensitive medical equipment such as an electroencephalogram (EEG) monitor. Brain waves provide an indication of the mental state of an individual. In other words, the appearance of brain waves is directly connected to what a person is doing, thinking or feeling. The different Brain states are: Gamma, Beta, Alpha, Theta, Delta. You have your own unique brain wave patterns that function habitually. Some of these brain wave habits are useful, and others need some fine-tuning. When your brain is functioning efficiently, your brain waves are “in sync” with your activity, but stress or lack of sleep can interfere with this natural harmonious relationship. To restore this harmony, at Gaia Meditation, we have developed a wide range of free audio programs, including meditation music, relaxation music, sleep music and plenty other Sound Healing programs.

2. The other thing you cannot afford to do is evaluate whether or not a technique is having an effect based upon having (or not having) any of those superficial, irrelevant, distracting phenomena discussed above, like face flushing, seeing light swirls, having sensations of this, that or the other thing, etc. Those kinds of phenomena will just lead you down the wrong path and steer you away from the true benefits of meditation. If you’ve already fallen into the trap of this sort of conditioning, using something like the Release Technique, the Sedona Method, or even EFT can be helpful in breaking established conditioned associations.
Regarding split hemisphere isochronic tones. Think of this as two separate isochronic tones tracks playing independently of each other, one playing in one ear and the other one in the opposite ear. Better still, imagine someone playing and recording a drum beat at a rate of 5 taps per second (5Hz – 5 cycles per second). Then a separate recording of a drum beat is made at a rate of 10 taps per second (10 Hz). You then make an audio track where the left ear/channel hears the 5 drum beats recording and the right ear/channel hears the 10 beat recording. With headphones on, each ear can only hear each respective drum beat and not the other. So you are hearing two different beat recordings at the same time, but it’s different in each ear. A split hemisphere isochronic tones track works just the same. You hear two beats at the same time, not two tones as with binaural beats that create a single beat, but two different speeds of beats in each ear. This is what enables you to stimulate and influence each side of the brain with a different frequency of beat. Binaural beats can only stimulate and influence a whole brain effect using a single beat.
To use your senses to quickly relieve stress, you first need to identify the sensory experiences that work best for you. This can require some experimentation. As you employ different senses, note how quickly your stress levels drop. And be as precise as possible. What is the specific kind of sound or type of movement that affects you the most? For example, if you’re a music lover, listen to many different artists and types of music until you find the song that instantly lifts and relaxes you.
Transparent Corp's Research Area is arguably the most comprehensive resource for collated brainwave entrainment research.   Update: the main research area on Transparent Corp's website is currently being updated, so it is offline.  However, you can still access their peer-reviewed research paper as a PDF here: “A Comprehensive Review of the Psychological Effects of Brainwave Entrainment“.
Effects on cortisol: The hormone cortisol is commonly associated with stress, and when levels are higher than usual, it can have a negative impact on the body. High levels of cortisol can lead to a range of conditions, including Cushing syndrome, menstrual cycle and female libido changes, anxiety, and depression. Dr. Giampapa noted a reduction of cortisol of up to 70-80 percent in several study participants.

These select frequencies and tones reduce the brain's filtering effect and allows consciousness to be set free. Each recording includes binaural beats, monaural beats, isochronic tones and other sound patterns, combined to deliver a range of delta, theta and alpha rhythms that draw your brain into hypnagogia, the transitional state between wakefulness and sleep.
The Frequency following response (FFR), also referred to as Frequency Following Potential (FFP), is a specific response to hearing sound and music, by which neural oscillations adjust their frequency to match the rhythm of auditory stimuli. The use of sound with intent to influence cortical brainwave frequency is called auditory driving,[39][40] by which frequency of neural oscillation is 'driven' to entrain with that of the rhythm of a sound source.[41][42]
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